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Literature summary for 2.3.1.5 extracted from
- Loss of human arylamine N-acetyltransferase I regulates mitochondrial function by inhibition of the pyruvate dehydrogenase complex (2019), Int. J. Biochem. Cell Biol., 110, 84-90 .
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P18440 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HT-29 cell | - |
Homo sapiens | - |
| MDA-MB-231 cell | - |
Homo sapiens | - |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | NAT1 deletion decreases oxidative phosphorylation with a significant loss in respiratory reserve capacity in both MDA-MB-231 and HT-29 cell lines. There is a decrease in glycolysis without a change in glucose uptake. The changes in mitochondrial function are due to a decrease in pyruvate dehydrogenase activity. Pyruvate dehydrogenase activity is attenuated either by an increase in phosphorylation or a decrease in total protein expression | Homo sapiens |
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Release 2023.1 (January 2023)
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